Targeting constitutive NF-κB specifically in tumor cells

Targeting constitutive NF-κB specifically in tumor cells

NF-κB transcription factors are the key regulators of innate and adaptive immune responses, inflammation, and cell survival [1]. Considerable evidences indicate that NF-κB plays important roles in carcinogenesis, cancer progression, metastasis and drug resistance, and therefore NF-κB has been regarded as one of the most important targets for cancer therapy [2]. However, the application of inhib...

P133: Targeting NF-Κb Signaling Pathway as Potential Therapeutic with Curcumin in Treatment of Multiple Sclerosis

Curcumin is active component of turmeric and isolated from the rhizome of turmeric, a phenolic natural product. One of inflammatory disease is multiple sclerosis, a multifocal chronic autoimmune inflammatory disease of the CNS, which is also known as a perivascular demyelinating disease. Studies have been shown that neuro-inflammation can have both harmful and beneficial effects on the neuronal...

“Re-educating” tumor-associated macrophages by targeting NF-κB

The nuclear factor kappaB (NF-kappaB) signaling pathway is important in cancer-related inflammation and malignant progression. Here, we describe a new role for NF-kappaB in cancer in maintaining the immunosuppressive phenotype of tumor-associated macrophages (TAMs). We show that macrophages are polarized via interleukin (IL)-1R and MyD88 to an immunosuppressive "alternative" phenotype that requ...

Targeting NF-κB in Waldenstrom Macroglobulinemia

Lactate does not activate NF-κB in oxidative tumor cells

The lactate anion is currently emerging as an oncometabolite. Lactate, produced and exported by glycolytic and glutaminolytic cells in tumors, can be recycled as an oxidative fuel by oxidative tumors cells. Independently of hypoxia, it can also activate transcription factor hypoxia-inducible factor-1 (HIF-1) in tumor and endothelial cells, promoting angiogenesis. These protumoral activities of ...